phospho-PDPK1 (Ser393) Rabbit pAb (一抗) | Bioss
概述
PDK1是蛋白激酶B(PKB)的上游激酶，通过与3,4,5三磷酸磷脂酰肌醇作用激活相邻的PKB分子。PDK1能够激活包含PKB在内的一系列的AGC激酶家族成员。从而调节细胞代谢，生长，扩散，生存，抗凋亡等诸多生理过程。
PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases.
PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
相关产品
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靶标
Contains 1 PH domain.
Contains 1 protein kinase domain.