Name: 连环蛋白delta-1重组兔单抗（CTNND1 Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-60229R
Availability: InStock

概述

产品编号

bsm-60229R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

CTNND1 Recombinant Rabbit mAb

中文名称

连环蛋白delta-1重组兔单抗

英文别名

BCDS2; CAS; CTNND; P120CAS; P120CTN; p120; p120(CAS); p120(CTN); Catns; mKIAA0384; CTND1_HUMAN; CTNND1; Cadherin-associated Src substrate (CAS); p120 catenin (p120(ctn)); KIAA0384; CTND1_MOUSE; catenin delta 1; catenin (cadherin-associated protein), delta 1

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human delta Catenin: 900-968

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

G11E8

理论分子量

106 kDa

检测分子量

90-105 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Catenins

Stem Cells > Signaling Pathways > Wnt > Cytoplasmic

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 1500 Human

Entrez Gene : 12388 Mouse

Entrez Gene : 311163 Rat

Omim : 601045 Human

SwissProt : O60716 Human

SwissProt : P30999 Mouse

Unigene : 166011 Human

Unigene : 35738 Mouse

Unigene : 9435 Rat

产品介绍

p120-连环素也可能参与细胞侵入力调节.

背景资料

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

基因名

CTNND1

蛋白名

Catenin delta-1

亚基

Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.

亚细胞定位

Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.

组织特异性

Expressed in vascular endothelium.

翻译后修饰

Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.

相似性

Belongs to the beta-catenin family.
Contains 10 ARM repeats.

功能

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.