Cardiac Troponin I-C (cTnI-C)

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货号：V3501

产品详情

概述

产品编号

V3501

英文名称

Cardiac Troponin I-C (cTnI-C) Mouse mAb

中文名称

心肌肌钙蛋白单克隆抗体

英文别名

troponin I type 3 (cardiac); Cardiac troponin I; Troponin I, cardiac muscle; Cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC-1; TNNC1; TNNI3; Troponin I cardiac; Troponin I cardiac muscle; Troponin I cardiac muscle isoform; Troponin I type 3 cardiac; troponin I, cardiac 3; TroponinI; Troponin I; TNNI3_HUMAN.

抗体来源

Mouse

免疫原

Recombinant human Cardiac Troponin I-C

亚型

IgG1

性状

Liquid

纯化方法

affinity purified by Protein G

克隆类型

Monoclonal

克隆号

5D12K

理论分子量

23 kDa

浓度

＞1mg/ml

储存液

0.01M PBS (pH7.4) with 0.02% Proclin300.

研究领域

Cardiovascular > Heart > Contractility > Contractile Proteins > Troponin

Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Troponin

SWISS

P19429

Gene ID

7137

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 7137 Human

Entrez Gene : 21954 Mouse

Entrez Gene : 100049696 Pig

Entrez Gene : 29248 Rat

Omim : 191044 Human

SwissProt : P19429 Human

SwissProt : P48787 Mouse

SwissProt : P23693 Rat

Unigene : 709179 Human

Unigene : 27674 Mouse

Unigene : 64141 Rat

产品介绍

心肌肌钙蛋白（Cardiac Troponin CTn1）是心肌收缩的调节蛋白，存在于心肌收缩蛋白的细肌丝上。肌钙蛋白的作用之一是把原肌凝蛋白（Tropomyosin.Tm）附着于肌动蛋白（Action.A）上、主要用于心肌功能方面的研究。

背景资料

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

产品应用

产品应用: ELISA=1:5000-10000

交叉反应

交叉反应: Human

靶标

基因名

TNNI3

蛋白名

Troponin I, cardiac muscle

亚基

Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1.

翻译后修饰

Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).

疾病

Defects in TNNI3 are the cause of familial hypertrophic cardiomyopathy type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in TNNI3 are the cause of familial restrictive cardiomyopathy type 1 (RCM1) [MIM:115210]. RCM1 is a heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

相似性

Belongs to the troponin I family.

功能

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

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