Vesicular Acetylcholine Transporter Rabbit pAb (一抗) | Bioss

bs-1833R

Vesicular Acetylcholine Transporter Rabbit pAb

囊泡乙酰胆碱通道抗体

CMS21; VACHT; VAT; rVAT; VACHT_HUMAN; SLC18A3; Solute carrier family 18 member 3; VACHT_MOUSE; VACHT_RAT; solute carrier family 18 member A3; solute carrier family 18 (vesicular acetylcholine transporter), member 3

Rabbit

KLH conjugated synthetic peptide derived from human VAT: 201-300/532

IgG

Liquid

affinity purified by Protein A

Polyclonal

57 kDa

60 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Vesicular Acetylcholine Transporter (VAChT), (~70kD protein), belongs to the family of vesicular monoamine transporters(VMATs), which include VMAT1 and VMAT2 and the C.elegans putative ACh transporter unc-17. Members of this family function to concentrate neurotransmitters into synaptic vesicles through exchange of protons for neurotransmitters. VAChT is a functional transporter for the neurotransmitter acetylcholine(ACh). ACh is synthesized in the cytoplasm by choline acetyl transferase (ChAT) and transported by VAChT into synaptic vesicles where it is stored until released. After release from presynaptic nerve terminals ACh is hydrolyzed by extracellular ACh-esterases(AChE) to choline and acetate.
VAChT mRNA is expressed in all known major cholinergic neurons in the central and peripheral nervous system. VAChT is abundantly expressed in the CNS and is mainly localized in small synaptic vesicles in cholinergic nerve terminals. VAChT provides a specific marker for cholinergic neurons for the study of cholinergic transmission in experimental models, in Alzheimer’s disease and other nervous system disorders.