8-OHdG (DNA/RNA Damage) Mouse mAb (一抗) - WB,IHC-P,IHC-F,IF,ELISA | Bioss

bsm-1278M

小分子抗体、药物靶点抗体

8-OHdG (DNA/RNA Damage) Mouse mAb

8-羟基脱氧鸟苷抗体

8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7, 8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7, 8-dihydro-2'-deoxyguanosine; 8-Oxo-7, 8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-7, 8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine; ; 8-OHdG;

Mouse

KLH conjugated synthetic peptide derived from human 8-OHdG/DNA/RNA Damage

IgM, k

Liquid

affinity purified by Protein A

Monoclonal

10E7

88847-89-6

0.283 kDa

1mg/ml

PBS with 0.02% Proclin300 and 0.1% Gelatin.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

8-OHDG作为内源性及外源性因素对DNA氧化损伤作用的生物标志物，是一个极有前途的指标，通过8-OHDG的检测可以评估体内氧化损伤和修复的程度，氧化应激与DNA损伤的相互关系，对研究退行性疾病、衰老机制、癌发生机制、环境毒物与氧化应激的关系等均有重要的意义，也可以用来评价抗氧化剂治疗DNA氧化损伤的效果。已经证实，饮食、超氧化物歧化酶、Melatonin等对8-OHDG水平具有调节作用。近期日本学者制成一种抗氧化作用鸡尾酒，由葵花籽、绿茶和维生素c组成，证实了对FeC12诱导的8-OHDG异常增加有回调作用。随着研究的深入，8-OHDG的应用范围必将越来越广，但到目前为止，各种检测方法都还需进一步完善，因而深入开展这项研究工作将有十分重要的实际意义。

8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.