This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken
1:500-2000
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken)
相关产品
暂无相关产品
靶标
基因名
BACH1
蛋白名
Transcription regulator protein BACH1
亚细胞定位
Nucleus.
相似性
Belongs to the bZIP family. CNC subfamily.
Contains 1 BTB (POZ) domain.
Contains 1 bZIP domain.
功能
Transcriptional regulator that acts as repressor or activator. Binds, in-vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.