The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Rat
1:500-2000
IHC-P
Rat
1:100-500
IHC-F
Rat
1:100-500
IF
Rat
1:100-500
交叉反应
交叉反应: Rat
相关产品
暂无相关产品
靶标
基因名
TSHB
蛋白名
Thyrotropin subunit beta
亚基
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
亚细胞定位
Secreted.
相似性
Belongs to the glycoprotein hormones subunit beta family.
功能
Indispensable for the control of thyroid structure and metabolism.