CAMK2A + CAMK2B + CAMK2D Rabbit pAb (一抗) | Bioss
货号：bs-0541R
产品详情
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常见问题
概述
产品编号
bs-0541R
英文名称
CAMK2A + CAMK2B + CAMK2D Rabbit pAb
中文名称
钙/钙调素依赖蛋白激酶2b/2γ抗体
英文别名
CAMKA; CaMKIINalpha; CaMKIIalpha; MRD53; MRT63; CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54; CAMKD; CAMK; CAMK-II; CAMKG; MRD59; 2810011D23Rik; 8030469K03Rik; CaMK II; [d]-CaMKII; CaMKII; mKIAA0968; Ck2b; CAMK1; Camki; RATCAMKI; PK2CDD; PKCCD; KCC2D_BOVIN; CAMK2D; CaM kinase II subunit delta; CaMK-II subunit delta; 2.7.11.17; KCC2B_BOVIN; CAMK2B; CaM kinase II subunit beta; CaMK-II subunit beta; KCC2B_HUMAN; KCC2G_HUMAN; CAMK2G; CaM kinase II subunit gamma; CaMK-II subunit gamma; KCC2D_HUMAN; KCC2A_HUMAN; CAMK2A; CaM kinase II subunit alpha; CaMK-II subunit alpha; KIAA0968; KCC2A_MOUSE; KCC2B_MOUSE; KCC2D_MOUSE; Kiaa4163; KCC2G_MOUSE; KCC2B_RAT; KCC2A_RAT; KCC2G_RAT; KCC2D_RAT; calcium/calmodulin dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; CaM-kinase II alpha chain; calcium/calmodulin-dependent protein kinase II alpha-B subunit; CaM kinase II alpha subunit; CaMK-II alpha subunit; calcium/calmodulin-dependent protein kinase type II alpha chain
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CaMK2 beta/ gamma/ delta: 1-100/479
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
53-73 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CaMK2b也是丝/苏氨基酸激酶的一种，同属于Ca++/钙调素依赖性蛋白质激酶家族成员。钙／钙调素依赖性蛋白激酶Ⅱb（CaMKⅡb）广泛分布于中枢神经系统内，参与调节神经递质的合成释放、信号转导和突触可塑性的形成以及磷酸化蛋白
背景资料
bs-0541P is one synthetic peptide derived from human CaMK2 beta/ gamma/ delta.
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| ICC/IF | Human | Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
CAMK2A
蛋白名
Calcium/calmodulin-dependent protein kinase type II subunit alpha
亚基
CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.
亚细胞定位
Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts.
组织特异性
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
翻译后修饰
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
相似性
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
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具体参考文献:bs-0541R 被引用于2文献中