CD33 mAb (一抗) - Flow-Cyt | Bioss
货号：bsm-43662M
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概述
产品编号
bsm-43662M
英文名称
CD33 mAb
中文名称
CD33单克隆抗体
英文别名
CD33rSiglec; SIGLEC-3; SIGLEC3; p67; gp67; CD33_HUMAN; CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); CD33_MOUSE;
免疫原
Recombinant human CD33 protein: 18-259/364
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Monoclonal
克隆号
2E3
理论分子量
40 kDa
浓度
1mg/ml
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CD33(Siglec-3)也是急性淋巴细胞白血病抗原,细胞表面跨膜糖蛋白.CD33表达于早期B淋巴细胞,某些粒性白细胞,骨髓基质细胞,部分上皮组织及其起源的肿瘤细胞中也有表达.主要应用于某些恶性淋巴瘤和白血病的分型.
背景资料
Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| Flow-Cyt | Human | 1:100-200 |
交叉反应
交叉反应: Human
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靶标
基因名
CD33
蛋白名
Myeloid cell surface antigen CD33
亚基
Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
亚细胞定位
Cell membrane; Single-pass type I membrane protein.
组织特异性
Monocytic/myeloid lineage cells.
翻译后修饰
Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11.
Phosphorylation of Tyr-358 is involved in binding to PTPN6.
Phosphorylation of Tyr-358 is involved in binding to PTPN6.
相似性
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
功能
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
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