Aspartate Aminotransferase Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,Flow-Cyt,ICC/IF,IF | Bioss
Rrmab?兔单抗
货号：bsm-63078R
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概述
产品编号
bsm-63078R
产品类型
重组兔单抗
英文名称
Aspartate Aminotransferase Recombinant Rabbit mAb
中文名称
谷草转氨酶重组兔单抗
英文别名
AATC_HUMAN; GOT1; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic (cCAT); Glutamate oxaloacetate transaminase 1; Transaminase A; 2.6.1.1; 2.6.1.3; AST; AST1; ASTQTL1; GIG18; SGOT; cCAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human GOT1: 150-230/413
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2F11
理论分子量
46 kDa
检测分子量
41 kDa
浓度
1mg/ml
储存液
10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Aspartate Aminotransferase [Glutamate oxaloacetate transaminase] is a ubiquitous pyridoxal phosphate-dependent enzyme which exists in both mitochondrial and cytosolic forms. The enzyme plays an important role in amino acid metabolism and in the urea and tricarboxylic acid cycles. The 2 isoenzymes are homodimeric. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic. Although the mitochondrial and soluble forms of GOT are coded by different chromosomes, the 2 show close homology in amino acid sequence and were presumably derived from a common ancestral gene.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
GOT1
蛋白名
Aspartate aminotransferase, cytoplasmic
亚基
Homodimer.
亚细胞定位
Cytoplasm.
相似性
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
功能
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
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