KAT4/TAF1 Rabbit pAb (一抗) | Bioss
货号：bs-2812R
产品详情
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概述
产品编号
bs-2812R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
KAT4/TAF1 Rabbit pAb
中文名称
细胞周期基因1蛋白抗体
英文别名
BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4; MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A; TAFII-250; TAFII250; XDP; B430306D02Rik; Ccg-1; RGD1562050; TAF1_HUMAN; TAF1; Cell cycle gene 1 protein; TBP-associated factor 250 kDa (p250); Transcription initiation factor TFIID 250 kDa subunit (TAF(II)250 | TAFII-250 | TAFII250); 2.3.1.48; 2.7.11.1; TAF1_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human TAF1
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
200 kDa
检测分子量
300 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 1:100-500 |
| ELISA | Human, Mouse, Rat, Cow, Chicken, Dog, Horse | 1:5000-10000 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Cow, Chicken, Dog, Horse)
相关产品
暂无相关产品
靶标
基因名
TAF1
蛋白名
Transcription initiation factor TFIID subunit 1
亚基
TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts with SV40 Large T antigen.
亚细胞定位
Nucleus.
翻译后修饰
Phosphorylated by casein kinase II in vitro.
疾病
Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:314250]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.
相似性
Belongs to the TAF1 family.
Contains 2 bromo domains.
Contains 1 HMG box DNA-binding domain.
Contains 2 protein kinase domains.
Contains 2 bromo domains.
Contains 1 HMG box DNA-binding domain.
Contains 2 protein kinase domains.
功能
Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
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