相关死亡促进因子BAD重组兔单抗

bsm-63058R

重组兔单抗、mIHC精品抗体

BAD Recombinant Rabbit mAb

相关死亡促进因子BAD重组兔单抗

BBC2; BCL2L8; Bad_v1; Bad_v2; BAD_HUMAN; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8 (Bcl2-L-8); Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; BBC6; BAD_MOUSE; BAD_RAT;

Rabbit

A synthesized peptide derived from human BAD: 1-42

IgG

Liquid

affinity purified by Protein A

Recombinant

12H7

18 kDa

10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BAD是BCL2/BAX、BCL-XL/BAX异二聚体的负调节基因。BAD是BCL2/BCL-XL相关死亡促进因子，作为BCL2、 bCL-XL异二聚体伴分子而促进细胞凋亡。
有学者认为：BAD缺乏典型的羧基端跨膜结构，提示其并非一完整膜蛋白。与同BCL2作用相比，BAD与BCL-XL的结合更强，BAD以浓度依赖性方式替换BCL-XL/BAX、BCL2/BAX异二聚体中的BAX，使BAX游离而促进细胞凋亡。当一细胞系的所有细胞内异二聚体（BCL-XL/BAX和BCL2/BAX）的含量≥50%时，则细胞耐受凋亡；而当细胞内BAX同二聚体＞80%时且在适当信号诱导下则细胞出现凋亡。这表明BAD通过调节BAX同二聚体与异二聚体量的比值而介导凋亡。

Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.