微管蛋白β tubulin/Tubulin β（内参）重组兔单抗
Rrmab®兔单抗
货号：bsm-33034R
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概述
产品编号
bsm-33034R
产品类型
内参抗体、重组兔单抗、宠物抗体、农牧业/家禽抗体、mIHC精品抗体
英文名称
Beta tubulin Recombinant Rabbit mAb
中文名称
微管蛋白β tubulin/Tubulin β（内参）重组兔单抗
英文别名
CDCBM6; CSCSC1; M40; OK/SW-cl.56; TUBB1; TUBB5; B130022C14Rik; M(beta)5; Tubb; TBB5_HUMAN; Tubulin beta-5 chain; TBB5_MOUSE; TBB5_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Beta tubuli
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7G3
理论分子量
50 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
结构蛋白（Structural Proteins）
tubulin是一种大量存在于哺乳动物脑组织中的微管亚基蛋白，在结构上是由两个极为相近的α和β亚基组成的二聚体、多聚体形成微管细丝，是微管的主要成分。
微管蛋白是球形分子, 有两种类型:α微管蛋白(α-tubulin)货号：bs-0195R和β微管蛋白(β-tubulin), 这两种微管蛋白具有相似的三维结构, 能够紧密地结合成二聚体, 作为微管组装的亚基。 α亚基由450个氨基酸组成, β亚基是由455个氨基酸组成, 这两种亚基有35～40%的氨基酸序列同源, 表明编码它们的基因可能是由同一原始祖先演变而来.
tubulin是一种大量存在于哺乳动物脑组织中的微管亚基蛋白，在结构上是由两个极为相近的α和β亚基组成的二聚体、多聚体形成微管细丝，是微管的主要成分。
微管蛋白是球形分子, 有两种类型:α微管蛋白(α-tubulin)货号：bs-0195R和β微管蛋白(β-tubulin), 这两种微管蛋白具有相似的三维结构, 能够紧密地结合成二聚体, 作为微管组装的亚基。 α亚基由450个氨基酸组成, β亚基是由455个氨基酸组成, 这两种亚基有35～40%的氨基酸序列同源, 表明编码它们的基因可能是由同一原始祖先演变而来.
背景资料
This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Rabbit, Pig, Sheep, Cow, Chicken, Dog, GuineaPig, Monkey | 1:50000-200000 |
| IHC-P | Human, Mouse, Rat | Rabbit, Pig, Sheep, Cow, Chicken, Dog, GuineaPig, Monkey | 1:200-1000 |
| IHC-F | Human, Mouse, Rat | Rabbit, Pig, Sheep, Cow, Chicken, Dog, GuineaPig, Monkey | 1:200-1000 |
| IF | Human | 1:200-1000 | |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, GuineaPig, Monkey | 1μg/Test |
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, GuineaPig, Monkey | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, GuineaPig, Monkey)
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靶标
基因名
TUBB
蛋白名
Tubulin beta chain
亚基
Dimer of alpha and beta chains. May interact with RNABP10. Interacts with PIFO. Interacts with MX1.
亚细胞定位
Cytoplasmic, cytoskeleton.
组织特异性
Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
翻译后修饰
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
相似性
Belongs to the tubulin family.
功能
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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具体参考文献:bsm-33034R 被引用于1文献中
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