丝裂原活化蛋白激酶激酶2重组兔单抗

bsm-63042R

重组兔单抗

MEK2 Recombinant Rabbit mAb

丝裂原活化蛋白激酶激酶2重组兔单抗

CFC4; MAPKK2; MEK2; MKK2; PRKMK2; MK2; MP2K2_HUMAN; MAP2K2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2 (MEK 2); 2.7.12.2; MP2K2_MOUSE; MP2K2_RAT;

Rabbit

A synthesized peptide derived from human MEK2: 10-55

IgG

Liquid

affinity purified by Protein A

Recombinant

10C18

46 kDa

1mg/ml

10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

丝裂原活化蛋白激酶激酶(MAPKK)是信号转导途径中的重要成员。

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].