Human CK18 Ready-To-Use IHC Kit (免疫组化试剂盒) | Bioss

IHC0249H

Human CK18 Ready-To-Use IHC Kit

人细胞角蛋白18即用型免疫组化试剂盒

CK-18; CK18; CYK18; K18; Kerd; Krt1-18; KRT18; PIG46

IHC0249H is a ready-to-use IHC kit for staining of Human CK18. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.

FFPE tissue

Immunohistochemistry

Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.