KEAP1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-60935R

重组兔单抗

KEAP1 Recombinant Rabbit mAb

胞质接头蛋白Keap1重组兔抗体

INrf2; KLHL19; mKIAA0132; KEAP1_HUMAN; KEAP1; Cytosolic inhibitor of Nrf2 (INrf2); Kelch-like protein 19; KIAA0132; KEAP1_MOUSE; KEAP1_PIG; KEAP1_RAT; kelch like ECH associated protein 1; kelch-like family member 19

Rabbit

KLH conjugated synthetic peptide derived from human KEAP1

IgG

Liquid

affinity purified by Protein A

Recombinant

7B13

69 kDa

60-65 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Keap1是细胞抗氧化反应的重要调节蛋白，Keap1与Nrf2/ARE构成的信号通路在抗肿瘤、抗应激、调节GSH合成、抗凋亡、抗炎反应、神经保护等方面发挥着广泛的细胞保护作用。

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].

KEAP1

Kelch-like ECH-associated protein 1

Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1.

Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

Broadly expressed, with highest levels in skeletal muscle.

Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.

Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.