Bcl-2 Knockout Hela Cell Ripa Lysate (Pool) (KO细胞裂解液) | Bioss

Knockout achieved by using CRISPR/Cas9, Insertion of the selection cassette in exon 2.

SwissProt : P10415 Human

Entrez Gene : 596 Human

The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas.Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal.Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action.A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2.