Topoisomerase I Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-52531R

重组兔单抗、mIHC精品抗体

Topoisomerase I Recombinant Rabbit mAb

拓普西异构酶Ⅰ重组兔单抗

TOPI; D130064I21Rik; Top-1; Ab2-086; TOP1_HUMAN; TOP1; DNA topoisomerase I; 5.6.2.1; TOP1_MOUSE; TOP1_RAT; topoisomerase (DNA) I; Scl-70 antigen

Rabbit

A synthesized peptide derived from human Topoisomerase 1: 1-45

IgG

Liquid

affinity purified by Protein A

Recombinant

1D1

91 kDa

100 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

TOP1

DNA topoisomerase 1

Nucleus, nucleolus. Nucleus, nucleoplasm. Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli.

Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment.

Note=A chromosomal aberration involving TOP1 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with NUP98.

Belongs to the eukaryotic type I topoisomerase family.

The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another.