去泛素化酶22重组兔单抗
Rrmab®兔单抗
货号：bsm-63012R
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概述
产品编号
bsm-63012R
产品类型
重组兔单抗
英文名称
USP22 Recombinant Rabbit mAb
中文名称
去泛素化酶22重组兔单抗
英文别名
USP3L; UBP22_HUMAN; USP22; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22; 3.4.19.12; KIAA1063; UBP22_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human USP22: 1-200
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7A3
理论分子量
60
检测分子量
60
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
| ICC/IF | Mouse, Rat, Human | 1:50-200 | |
| IP | Mouse, Rat, Human | 1:20-50 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human)
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靶标
基因名
USP22
蛋白名
Ubiquitin carboxyl-terminal hydrolase 22
亚基
Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex.
亚细胞定位
Nucleus.
组织特异性
Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.
相似性
Belongs to the peptidase C19 family. UBP8 subfamily.
Contains 1 UBP-type zinc finger.
Contains 1 UBP-type zinc finger.
功能
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
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