Ubiquitin Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-63008R

重组兔单抗、mIHC精品抗体

Ubiquitin Recombinant Rabbit mAb

泛素蛋白重组兔单抗

HEL-S-50; Rps27a; Uba52; Ubb2; Ubc; UBB_BOVIN; UBB; UBB_HORSE; UBB_HUMAN; UBC_HUMAN; UBIQ_HUMAN; UBB_MOUSE; UBIQ_MOUSE; UBB_RAT; UBIQ_RAT; ubiquitin B; polyubiquitin B

Rabbit

A synthesized peptide derived from human Ubiquitin: 50-76

IgG

Liquid

affinity purified by Protein A

Recombinant

19D17

26 kDa

＞90 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

泛素及类泛素蛋白(Ubls) 存在在多种细胞中，有多种细胞调控的功能，如细胞增殖、凋亡、细胞周期及DNA修复等。但泛素途径的异常会导致人类疾病的产生，包括多种形式的肿瘤的发生，神经退变等都与泛素有关。

相关产品：
Ubiquitin 1-76 peptides (bs-10803P);

UBB

Polyubiquitin-B

Cytoplasm. Nucleus.

Belongs to the ubiquitin family.
Contains 9 ubiquitin-like domains.

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.