TIMP-1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-62994R

重组兔单抗

TIMP-1 Recombinant Rabbit mAb

金属蛋白酶组织抑制因子-1重组兔单抗

CLGI; EPA; EPO; HCI; TIMP; TIMP-1; TPA-S1; TIMP1_HUMAN; TIMP1; Erythroid-potentiating activity (EPA); Fibroblast collagenase inhibitor (Collagenase inhibitor); Tissue inhibitor of metalloproteinases 1 (TIMP-1); TIMP1_MOUSE; Collagenase inhibitor 16C8 fibroblast; TPA-induced protein; TIMP metallopeptidase inhibitor 1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)

Rabbit

A synthesized peptide derived from human TIMP1: 1-207/207

IgG

Liquid

affinity purified by Protein A

Recombinant

3G17

23 kDa

28 kDa

1mg/ml

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成与降解（Synthesis and Degradation）
TIMP1是基质金属蛋白酶的抑制酶，其功能与MMP相反，能抑制肿瘤细胞的浸润和转移，主要用于各种恶性肿瘤如乳腺癌等的研究。TIMP-1是一种28kDa的糖蛋白，主要分泌细胞为多种结缔组织细胞，被认为是组织中MMPs活性的主要调节者，它可以和MMPs家族成员以共价键方式形成1:1的复合物，从而发挥其抑制作用。在正常生理条件下，MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的，一旦它们之间的比例失调，就会造成一系列的病理状态。

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.

TIMP1

Metalloproteinase inhibitor 1

Secreted.

The activity of TIMP1 is dependent on the presence of disulfide bonds.

Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.