Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs.Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Induces permissive chromatin accessibilty and CpG methylation in IFNG.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:500-2000
Flow-Cyt
Human
1:50-100
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
TBX21
蛋白名
T-box transcription factor TBX21
亚细胞定位
Nucleus.
组织特异性
T-cell specific.
疾病
Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
相似性
Contains 1 T-box DNA-binding domain.
功能
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.