T细胞介导的转录调节因子Tbx21重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
T细胞介导的转录调节因子Tbx21重组兔单抗
货号:bsm-62988R
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概述

产品编号
bsm-62988R
产品类型
重组兔单抗
英文名称
Tbx21 Recombinant Rabbit mAb
中文名称
T细胞介导的转录调节因子Tbx21重组兔单抗
英文别名
IMD88; T-PET; T-bet; TBET; TBLYM; TBT1; TBX21_HUMAN; TBX21; T-box protein 21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM; TBX21_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human TBX21: 500-535/535
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
19E12
理论分子量
58
检测分子量
58
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs.Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Induces permissive chromatin accessibilty and CpG methylation in IFNG.
T细胞介导的转录调节因子Tbx21重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman1:500-2000
Flow-CytHuman1:50-100

交叉反应

交叉反应: Human

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靶标

基因名
TBX21
蛋白名
T-box transcription factor TBX21
亚细胞定位
Nucleus.
组织特异性
T-cell specific.
疾病
Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
相似性
Contains 1 T-box DNA-binding domain.
功能
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

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