Tbx21 Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-62988R

重组兔单抗

Tbx21 Recombinant Rabbit mAb

T细胞介导的转录调节因子Tbx21重组兔单抗

IMD88; T-PET; T-bet; TBET; TBLYM; TBT1; TBX21_HUMAN; TBX21; T-box protein 21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM; TBX21_MOUSE; T-box transcription factor 21; T-box 21; T-box transcription factor expressed in T cells

Rabbit

A synthesized peptide derived from human TBX21: 500-535/535

IgG

Liquid

affinity purified by Protein A

Recombinant

19E12

58 kDa

68 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs.Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Induces permissive chromatin accessibilty and CpG methylation in IFNG.

TBX21

T-box transcription factor TBX21

Nucleus.

T-cell specific.

Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.

Contains 1 T-box DNA-binding domain.

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.