长链脂肪酸转运蛋白4重组兔单抗
Rrmab®兔单抗
货号：bsm-62978R
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概述
产品编号
bsm-62978R
产品类型
重组兔单抗
英文名称
FATP4 Recombinant Rabbit mAb
中文名称
长链脂肪酸转运蛋白4重组兔单抗
英文别名
ACSVL4; FATP4; IPS; S27A4_HUMAN; SLC27A4; FATP-4; Fatty acid transport protein 4; Arachidonate--CoA ligase; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 4; Very long-chain acyl-CoA synthetase 4 (ACSVL4); S27A4_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human FATP 4: 400-643
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
20C7
理论分子量
72
检测分子量
72
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Fatty acids
Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes.Appears to be the principal fatty acid transporter in small intestinal enterocytes.Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat | 1:500-2000 |
| Flow-Cyt | Mouse, Human, Rat | 1:50-100 | |
| ICC/IF | Mouse, Human, Rat | 1:50-200 |
交叉反应
交叉反应: Mouse (predicted: Human, Rat)
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靶标
基因名
SLC27A4
蛋白名
Long-chain fatty acid transport protein 4
亚细胞定位
Membrane; Multi-pass membrane protein
组织特异性
Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.
疾病
Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS) [MIM:608649]. A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations.
相似性
Belongs to the ATP-dependent AMP-binding enzyme family.
功能
nvolved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids
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