蛋白激酶C重组兔单抗
Rrmab®兔单抗
货号：bsm-62958R
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概述
产品编号
bsm-62958R
产品类型
重组兔单抗
英文名称
PKC Recombinant Rabbit mAb
中文名称
蛋白激酶C重组兔单抗
英文别名
PKC-gamma; PKCC; PKCG; PKCI(3); PKCgamma; SCA14; Prkcc; PKC; PKCI; Prkc; RATPKCI; KPCG_HUMAN; PRKCG; 2.7.11.13; KPCG_MOUSE; KPCG_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PKC: 300-500/671
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
11H15
理论分子量
37,40,68-84
检测分子量
77
浓度
1mg/ml
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PRKCG
蛋白名
Protein kinase C gamma type
亚基
Interacts with GRIA4. Interacts with CDCP1. Interacts with TP53INP1 and p53/TP53.
亚细胞定位
Cytoplasm.Cell membrane.
组织特异性
Expressed in Purkinje cells of the cerebellar cortex.
翻译后修饰
Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins,
JPH3 and JPH4.Ubiquitinated.
JPH3 and JPH4.Ubiquitinated.
疾病
Defects in PRKCG are the cause of spinocerebellar ataxia type 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA).
相似性
Belongs to the protein kinase superfamily.
AGC Ser/Thr protein kinase family.
PKC subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 C2 domain.
Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 protein kinase domain.
AGC Ser/Thr protein kinase family.
PKC subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 C2 domain.
Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 protein kinase domain.
功能
This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
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