Ras Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,ICC/IF,IF,IP | Bioss

bsm-62921R

重组兔单抗

Ras Recombinant Rabbit mAb

原癌基因Ras重组兔单抗

ALPS4; CMNS; KRAS; N-ras; NCMS; NRAS1; NS6; RASN_HUMAN; NRAS; Transforming protein N-Ras; 3.6.5.2; HRAS1; NRAS proto-oncogene, GTPase; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog

Rabbit

A synthesized peptide derived from human Ras: 25-50

IgG

Liquid

affinity purified by Protein A

Recombinant

8H2

21,22 kDa

22 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞信号转导系统紊乱是肿瘤细胞生长的重要特征之一，Ras蛋白参与体内多种细胞信号转导途径而发挥作用,而原癌基因N-ras是一种多功能的细胞因子，广泛存在于自然界，N-ras在多种细胞生命活动中起极为重要的作用，包括细胞的增殖、分化和细胞骨架的构建等等，该抗体主要用于肿瘤方面的研究。

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

NRAS

GTPase NRas

Interacts (active GTP-bound form preferentially) with RGS14. Interacts (active GTP-bound form) with RASSF7.

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.

Widely expressed.

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).

Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry.
Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Note=The disease is caused by mutations affecting the gene represented in this entry.
Autoimmune lymphoproliferative syndrome 4 (ALPS4) [MIM:614470]: A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies. Note=The disease is caused by mutations affecting the gene represented in this entry.

Belongs to the small GTPase superfamily. Ras family.

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.