肌原调节蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-62915R
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概述
产品编号
bsm-62915R
产品类型
重组兔单抗
英文名称
MYOD1 Recombinant Rabbit mAb
中文名称
肌原调节蛋白重组兔单抗
英文别名
MyoD; CMYO17; CMYP17; MYF3; MYODRIF; PUM; bHLHc1; Myod-1; MUF3; MYF-3; MYOD1_CHICK; MYOD1; MYOD1 homolog; CMD1; MYOD1_BOVIN; MYOD1_HUMAN; Class C basic helix-loop-helix protein 1 (bHLHc1); Myogenic factor 3 (Myf-3); MYOD1_MOUSE; MYOD1_PIG; MYOD1_RAT; MYOD1_SHEEP;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human MYOD1: 30-90/320
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
17F1
理论分子量
35
检测分子量
45
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
MYOD1
蛋白名
Myoblast determination protein 1
亚基
Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5 (By similarity).
亚细胞定位
Nucleus.
翻译后修饰
Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
Ubiquitinated on the N-terminus; which is required for proteasomal degradation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
Ubiquitinated on the N-terminus; which is required for proteasomal degradation.
相似性
Contains 1 bHLH (basic helix-loop-helix) domain.
功能
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
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