半乳糖凝集素3重组兔单抗
Rrmab®兔单抗
货号：bsm-62883R
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概述
产品编号
bsm-62883R
产品类型
重组兔单抗
英文名称
Galectin 3 Recombinant Rabbit mAb
中文名称
半乳糖凝集素3重组兔单抗
英文别名
CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2; GBP; L-34; Mac-2; AGE-R3; CBP30; gal-3; LEG3_HUMAN; LGALS3; 35 kDa lectin; Carbohydrate-binding protein 35 (CBP 35); Galactose-specific lectin 3; Galactoside-binding protein (GALBP); IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen; LEG3_MOUSE; L-34 galactoside-binding lectin; LEG3_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Galectin 3: 4-36/250
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
15E7
理论分子量
26
检测分子量
30
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
Galectin-3是Galectin（半乳凝素）家族的一员，能识别糖蛋白和糖脂的特异性低聚糖结构，参与多种生理和病理过程，包括细胞生长和凋亡、细胞黏附、新生血管形成和肿瘤浸润与转移等。Galectin-3在肿瘤的发生、发展及转移中起重要作用。
Galectin-3在某些肿瘤组织中高表达，其在不同类型肿瘤，如结直肠癌、胃癌、胰腺癌、甲状腺癌及肺癌等患者中的高表达水平，与低生存、肿瘤复发、预后差及对化疗药物敏感性降低相关对于某些肿瘤，Galectin-3有可能成为一个有价值的诊断标志和治疗靶点。
背景资料
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Rat | 1:500-2000 | |
| Flow-Cyt | Human, Rat | 1:50-100 | |
| ICC/IF | Human, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Rat
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靶标
基因名
LGALS3
蛋白名
Galectin-3
亚基
Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.
亚细胞定位
Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.
组织特异性
A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.
相似性
Contains 1 galectin domain.
功能
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
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