Galectin 3 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt | Bioss

bsm-62883R

重组兔单抗

Galectin 3 Recombinant Rabbit mAb

半乳糖凝集素3重组兔单抗

CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2; GBP; L-34; Mac-2; AGE-R3; CBP30; gal-3; LEG3_HUMAN; LGALS3; 35 kDa lectin; Carbohydrate-binding protein 35 (CBP 35); Galactose-specific lectin 3; Galactoside-binding protein (GALBP); IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen; LEG3_MOUSE; L-34 galactoside-binding lectin; LEG3_RAT; galectin 3; lectin, galactoside-binding, soluble, 3; advanced glycation end-product receptor 3

Rabbit

A synthesized peptide derived from human Galectin 3: 4-36/250

IgG

Liquid

affinity purified by Protein A

Recombinant

15E7

26 kDa

31 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Galectin-3是Galectin（半乳凝素）家族的一员，能识别糖蛋白和糖脂的特异性低聚糖结构，参与多种生理和病理过程，包括细胞生长和凋亡、细胞黏附、新生血管形成和肿瘤浸润与转移等。Galectin-3在肿瘤的发生、发展及转移中起重要作用。 Galectin-3在某些肿瘤组织中高表达，其在不同类型肿瘤，如结直肠癌、胃癌、胰腺癌、甲状腺癌及肺癌等患者中的高表达水平，与低生存、肿瘤复发、预后差及对化疗药物敏感性降低相关对于某些肿瘤，Galectin-3有可能成为一个有价值的诊断标志和治疗靶点。

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.

LGALS3

Galectin-3

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.

Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.

Contains 1 galectin domain.

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.