磷酸化蛋白激酶A α/β/γ重组兔单抗
Rrmab®兔单抗
货号：bsm-62860R
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概述
产品编号
bsm-62860R
产品类型
磷酸化抗体、重组兔单抗
英文名称
phospho-PKA C alpha/beta/gamma (T197) Recombinant Rabbit mAb
中文名称
磷酸化蛋白激酶A α/β/γ重组兔单抗
英文别名
PKA C alpha & beta & gamma (phospho-T197); p-PKA C alpha & beta & gamma; phospho-PKA C alpha & beta & gamma; p-PKACA & p-PKACB; BDPLT19; KAPG; PKACg; KAPCG_HUMAN; PRKACG; PKA C-gamma; 2.7.11.11;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PKA C alpha around the phosphorylation site of T197: RTW-pT-LCG
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5B5
理论分子量
40,41
检测分子量
40
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
Metabolism > Types of disease > Cancer
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > PKA
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PRKACG
蛋白名
cAMP-dependent protein kinase catalytic subunit gamma
亚基
A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
组织特异性
Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.
相似性
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
功能
Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
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