磷酸化心脏磷蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-62841R
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概述
产品编号
bsm-62841R
产品类型
磷酸化抗体、重组兔单抗、离子通道抗体
英文名称
phospho-PLB (Ser16) Recombinant Rabbit mAb
中文名称
磷酸化心脏磷蛋白重组兔单抗
英文别名
PLN | PLB (phospho-S16); p-PLB; phospho-PLB; p-PLN; CMD1P; CMH18; PLB; Plm; PPLA_BOVIN; PLN; PPLA_HUMAN; PPLA_MOUSE; PPLA_PIG; PPLA_RABIT; PPLA_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PLB around the phosphorylation site of S16: RA-pS-TIEM
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
10H6
理论分子量
6
检测分子量
11
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cardiovascular > Heart > Contractility > Inotropics
Cardiovascular > Vasculature > Vasodilation
Signal Transduction > Metabolism > Plasma Membrane > ATPases
Signal Transduction > Metabolism > Plasma Membrane > Channels
Signal Transduction > Signaling Pathway > Calcium Signaling
Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Human)
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靶标
基因名
PLN
蛋白名
Cardiac phospholamban
亚基
Homopentamer. Interacts with HAX1.
亚细胞定位
Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum.
组织特异性
Heart.
翻译后修饰
Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
疾病
Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in PLN are the cause of familial hypertrophic cardiomyopathy type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in PLN are the cause of familial hypertrophic cardiomyopathy type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
相似性
Belongs to the phospholamban family.
功能
Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
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