Name: 干扰素调节因子4重组兔单抗（IRF4 Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-62837R
Availability: InStock

概述

产品编号

bsm-62837R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

IRF4 Recombinant Rabbit mAb

中文名称

干扰素调节因子4重组兔单抗

英文别名

IMD131; LSIRF; MUM1; NF-EM5; SHEP8; IRF4_HUMAN; IRF4; IRF-4; Lymphocyte-specific interferon regulatory factor (LSIRF); Multiple myeloma oncogene 1; interferon regulatory factor 4

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human IRF4: 144-450/451

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

10H6

理论分子量

52 kDa

检测分子量

52 kDa

储存液

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

研究领域

Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors

Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes

Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

Tags & Cell Markers > Cell Type Markers > Tumor Associated

SWISS

Q15306

Gene ID

3662

保存条件

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 3662 Human

Omim : 601900 Human

SwissProt : Q15306 Human

Unigene : 401013 Human

产品介绍

转录调节因子（Transcriptin Regulators）
干扰素调节因子家族是一大类对干扰素起调控作用的转录因子的统称。一般认为干扰素调节因子(IRF)通过调节干扰素的表达而行使其抗病毒、应激、免疫调节功能。近年来，研究人员发现IRF在细胞凋亡、细胞周期、细胞分化、肿瘤发生中也起着重要的调节作用。

背景资料

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.

基因名

IRF4

蛋白名

Interferon regulatory factor 4

亚基

Interacts with the BATF-JUNB heterodimer. Interacts with BATF (via bZIP domain); the interaction is direct (By similarity). Interacts with SPIB and DEF6.

亚细胞定位

Nucleus.

组织特异性

Lymphoid cells.

翻译后修饰

Phosphorylation by ROCK2 regulates IL-17 and IL-21 production (By similarity).

疾病

Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.

相似性

Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

功能

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).