DUT Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF | Bioss
Rrmab?兔单抗
货号：bsm-62811R
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概述
产品编号
bsm-62811R
产品类型
重组兔单抗
英文名称
DUT Recombinant Rabbit mAb
中文名称
脱氧尿苷三磷酸酶DUT重组兔单抗
英文别名
BMFDMS; dUTPase; 5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Dutp; PIP4; DUT_HUMAN; DUT; dUTP pyrophosphatase; 3.6.1.23; DUT_RAT; PPAR-interacting protein 4 (PIP4);
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human DUT: 200-252
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1B5
理论分子量
27 kDa
检测分子量
20 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
dUTPase是机体中重要的水解酶，基本作用是把dUTP水解成dUMP和焦磷酸，不但可以提供给DNA的合成原料，还可以降低DNA突变的几率，对细胞遗传起到一定的稳定作用。
背景资料
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| Flow-Cyt | Human | 1:50-100 | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
DUT
蛋白名
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
亚基
Homotrimer.
亚细胞定位
Isoform 2: Nucleus. Isoform 3: Mitochondrion.
组织特异性
Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).
翻译后修饰
Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.
The initiator methionine is cleaved in isoform 2.
The initiator methionine is cleaved in isoform 2.
相似性
Belongs to the dUTPase family.
功能
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
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