血小板源性生长因子-B重组兔单抗
Rrmab®兔单抗
货号：bsm-62801R
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概述
产品编号
bsm-62801R
产品类型
重组兔单抗
英文名称
PDGF-B Recombinant Rabbit mAb
中文名称
血小板源性生长因子-B重组兔单抗
英文别名
IBGC5; PDGF-2; PDGF2; SIS; SSV; c-sis; PDGF-B; PDGFB_HUMAN; PDGFB; PDGF subunit B; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; PDGFB_MOUSE; PDGFB_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PDGF B: 200-241
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12F5
理论分子量
27
检测分子量
27
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Response to hypoxia
Cancer > Growth factors > PDGF
Cardiovascular > Atherosclerosis > Vascular Inflammation > Inflammatory mediators
Cardiovascular > Blood > Serum Proteins
Developmental Biology > Organogenesis > Angiogenesis and vasculogenesis
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
生长因子和激素（ Growth Factor and Hormones）
PDGF（platelet-dirived growth factor）是一种碱性蛋白，分为两个亚基（A、B链）通过二硫键结合而成的两条多肽链的异二聚体，分子量为28-35kDa。为促细胞分裂剂，可使小鼠成纤维细胞及其他多种细胞增殖。最新研究发现了PDGF家族两种新的基因PDGF-C、PDGF-D。
PDGF（platelet-dirived growth factor）是一种碱性蛋白，分为两个亚基（A、B链）通过二硫键结合而成的两条多肽链的异二聚体，分子量为28-35kDa。为促细胞分裂剂，可使小鼠成纤维细胞及其他多种细胞增殖。最新研究发现了PDGF家族两种新的基因PDGF-C、PDGF-D。
背景资料
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Rat | Mouse | 1:500-2000 |
交叉反应
交叉反应: Human, Rat (predicted: Mouse)
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靶标
基因名
PDGFB
蛋白名
Platelet-derived growth factor subunit B
亚基
Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1.
亚细胞定位
Secreted. Note=Released by platelets upon wounding.
组织特异性
Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
疾病
Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.
相似性
Belongs to the PDGF/VEGF growth factor family.
功能
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.
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