PDGF-B Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-62801R

重组兔单抗

PDGF-B Recombinant Rabbit mAb

血小板源性生长因子-B重组兔单抗

IBGC5; PDGF-2; PDGF2; SIS; SSV; c-sis; PDGF-B; PDGFB_HUMAN; PDGFB; PDGF subunit B; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; PDGFB_MOUSE; PDGFB_RAT; platelet derived growth factor subunit B; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); oncogene SIS; becaplermin

Rabbit

A synthesized peptide derived from human PDGF B: 200-241

IgG

Liquid

affinity purified by Protein A

Recombinant

12F5

27 kDa

27 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones）
PDGF（platelet-dirived growth factor）是一种碱性蛋白，分为两个亚基（A、B链）通过二硫键结合而成的两条多肽链的异二聚体，分子量为28-35kDa。为促细胞分裂剂，可使小鼠成纤维细胞及其他多种细胞增殖。最新研究发现了PDGF家族两种新的基因PDGF-C、PDGF-D。

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin.

PDGFB

Platelet-derived growth factor subunit B

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1.

Secreted. Note=Released by platelets upon wounding.

Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.

Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.

Belongs to the PDGF/VEGF growth factor family.

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.