Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:1000-2000
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
CFD
蛋白名
Complement factor D
亚细胞定位
Secreted.
疾病
Defects in CFD are the cause of complement factor D deficiency (CFD deficiency) [MIM:134350]. CFD deficiency predisposes to invasive meningococcal disease.
相似性
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
功能
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.