PCBP2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF,IP | Bioss

bsm-62729R

重组兔单抗、mIHC精品抗体

PCBP2 Recombinant Rabbit mAb

异构核糖核蛋白E2重组兔单抗

HNRNPE2; HNRPE2; hnRNP-E2; Hnrpx; alphaCP-2; PCBP2_HUMAN; PCBP2; Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2 (hnRNP E2); PCBP2_MOUSE; CTBP (CBP); Putative heterogeneous nuclear ribonucleoprotein X (hnRNP X); Cbp; Hnrnpx; poly(rC) binding protein 2; poly(rC)-binding protein 2; heterogenous nuclear ribonucleoprotein E2

Rabbit

A synthesized peptide derived from human PCBP2: 257-299

IgG

Liquid

affinity purified by Protein A

Recombinant

14H1

39 kDa

39-42 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.Major cellular poly(rC)-binding protein.Acts as a negative regulator of antiviral signaling .

PCBP2

Poly(rC)-binding protein 2

Identified in a mRNP complex, at least composed of DHX9,DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1,STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts with MAVS (via C-terminus) and ITCH (via WW domains).

Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Detected in all tissues examined.

Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.

Contains 3 KH domains.

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.