异构核糖核蛋白E2重组兔单抗
Rrmab®兔单抗
货号：bsm-62729R
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概述
产品编号
bsm-62729R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
PCBP2 Recombinant Rabbit mAb
中文名称
异构核糖核蛋白E2重组兔单抗
英文别名
HNRNPE2; HNRPE2; hnRNP-E2; Hnrpx; alphaCP-2; PCBP2_HUMAN; PCBP2; Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2 (hnRNP E2); PCBP2_MOUSE; CTBP (CBP); Putative heterogeneous nuclear ribonucleoprotein X (hnRNP X); Cbp; Hnrnpx;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PCBP2: 257-299
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
14H1
理论分子量
39
检测分子量
35,39
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.Major cellular poly(rC)-binding protein.Acts as a negative regulator of antiviral signaling .
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Mouse, Rat | Human | 1:100-500 |
| IHC-F | Mouse, Rat | Human | 1:100-500 |
| IF | Mouse, Rat | Human | 1:100-500 |
| ICC/IF | Human, Mouse, Rat | 1:50-200 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PCBP2
蛋白名
Poly(rC)-binding protein 2
亚基
Identified in a mRNP complex, at least composed of DHX9,DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1,STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts
with MAVS (via C-terminus) and ITCH (via WW domains).
亚细胞定位
Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
组织特异性
Detected in all tissues examined.
翻译后修饰
Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
相似性
Contains 3 KH domains.
功能
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
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