Required for anchoring microtubules to the centrosomes. Required for ciliation.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
Mouse, Rat
1:500-2000
ICC/IF
Human, Mouse, Rat
1:50-200
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
相关产品
暂无相关产品
靶标
基因名
CEP43
蛋白名
Centrosomal protein 43
亚基
Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.
亚细胞定位
Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin.
组织特异性
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
疾病
Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
相似性
Belongs to the FGFR1OP family. Contains 1 LisH domain.
功能
Required for anchoring microtubules to the centrosomes.