胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗
货号:bsm-62659R
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概述

产品编号
bsm-62659R
产品类型
重组兔单抗
英文名称
IGF2BP2 Recombinant Rabbit mAb
中文名称
胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗
英文别名
IMP-2; IMP2; VICKZ2; C330012H03Rik; Neilsen; RGD1305614; IF2B2_HUMAN; IGF2BP2; IGF2 mRNA-binding protein 2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2; IF2B2_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IGF2BP2: 500-599
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2B8
理论分子量
66
检测分子量
66,62
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation.Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability.
胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗胰岛素样生长因子ⅡmRNA结合蛋白2重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHumanMouse, Rat1:500-2000
IHC-PHuman, Mouse, Rat1:50-200
IHC-FHuman, Mouse, Rat1:50-200
IFHuman, Mouse, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
IGF2BP2
蛋白名
Insulin-like growth factor 2 mRNA-binding protein 2
亚基
Interacts with HNRPD and IGF2BP1.
亚细胞定位
Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa.
组织特异性
Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
相似性
Belongs to the RRM IMP/VICKZ family br>Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.
功能
Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs.

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