May play a role in lymphocyte recirculation by blocking LFA1 dependent cell adhesion. Mediates adhesive interactions important for antigen specific immune response, NK cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human
1:500-2000
IHC-P
Mouse
Human
1:50-200
IHC-F
Mouse
Human
1:50-200
IF
Mouse
Human
1:50-200
Flow-Cyt
Human
Mouse
1:50-100
IP
Human, Mouse
1:20-50
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
ICAM2
蛋白名
Intercellular adhesion molecule 2
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Expressed in endothelial cells and leukocytes. High levels found in lung.
相似性
Belongs to the immunoglobulin superfamily. ICAM family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
功能
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.