G蛋白偶联嘌呤受体p2y12重组兔单抗
Rrmab®兔单抗
货号：bsm-62569R
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概述
产品编号
bsm-62569R
产品类型
重组兔单抗
英文名称
P2Y12 Recombinant Rabbit mAb
中文名称
G蛋白偶联嘌呤受体p2y12重组兔单抗
英文别名
ADPG-R; BDPLT8; HORK3; P2T(AC); P2Y(12)R; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999; P2Y12_HUMAN; P2RY12; ADP-glucose receptor (ADPG-R); P2Y12 platelet ADP receptor (P2Y(ADP));
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human P2Y12: 120-347
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
17H15
理论分子量
39
检测分子量
50
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
P2RY12
蛋白名
P2Y purinoceptor 12
亚细胞定位
Cell membrane; Multi-pass membrane protein.
组织特异性
Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
疾病
Defects in P2RY12 are the cause of P2RY12 deficiency (P2RY12D) [MIM:609821]. It is a condition characterized by severe impairment of platelet response to ADP and abnormal bleeding marked by excessive posttraumatic and postsurgical blood loss.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.
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