抑凋亡基因bag1重组兔单抗
Rrmab®兔单抗
货号：bsm-62568R
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概述
产品编号
bsm-62568R
产品类型
重组兔单抗
英文名称
Bag1 Recombinant Rabbit mAb
中文名称
抑凋亡基因bag1重组兔单抗
英文别名
BAG-1; HAP; RAP46; BAG1_HUMAN; BAG1; Bcl-2-associated athanogene 1; BAG1_MOUSE; BAG1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human BAG1: 130-155
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
理论分子量
39
检测分子量
33,46,50
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Apoptosis Markers > Bcl 2 family
Cancer > Cell Death > Apoptosis > Metabolism
Cancer > Cell Death > Autophagy > Autophagosome
Cancer > Invasion/microenvironment > Apoptosis > Bcl 2 family
Cardiovascular > Atherosclerosis > Apoptosis
Cardiovascular > Heart > Autophagy > Autophagosome
Cell Biology > Apoptosis > Intracellular > Bcl2 Family
Metabolism > Pathways and Processes > Metabolism processes > Apoptosis
Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > Autophagosome
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
Bag1蛋白是一种多功能蛋白，起到抑凋亡的作用，与Bcl 2、Raf 1等联合，一同调节一些生长因子及其受体酪氨酸激酶，协同热休克蛋白70发挥转录调节的分子作用。
背景资料
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-1000 |
| IHC-P | Human | Mouse, Rat | 1:50-200 |
| IHC-F | Human | Mouse, Rat | 1:50-200 |
| IF | Human | Mouse, Rat | 1:50-200 |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
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靶标
基因名
BAG1
蛋白名
BAG family molecular chaperone regulator 1
亚基
Contains 1 BAG domain.
Contains 1 ubiquitin-like domain.
亚细胞定位
Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock; Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus and Cytoplasm. Nucleus. Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
组织特异性
Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines.
功能
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
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