TRPV5 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-62549R

重组兔单抗

TRPV5 Recombinant Rabbit mAb

辣椒素受体5重组兔单抗

CAT2; ECAC1; OTRPC3; D630033B11; TRPV5_HUMAN; TRPV5; Calcium transport protein 2 (CaT2); Epithelial calcium channel 1 (ECaC | ECaC1); Osm-9-like TRP channel 3 (OTRPC3); TRPV5_MOUSE; Epithelial calcium channel 1 (ECaC1); TRPV5_RAT; Calcium transporter 2 (CaT2); Ecac; transient receptor potential cation channel subfamily V member 5; epithelial calcium channel 1; transient receptor potential cation channel, subfamily V, member 5

Rabbit

A synthesized peptide derived from human TRPV5: 1-100

IgG

Liquid

affinity purified by Protein A

Recombinant

4D7

83 kDa

90 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine.Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules.The channel is activated by low internal calcium level and the current exhibits an inward rectification.

TRPV5

Transient receptor potential cation channel subfamily V member 5

Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation (By similarity).

Apical cell membrane. Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3.

Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.

Glycosylated.

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.
Contains 5 ANK repeats.

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.