Rho GTP酶激活蛋白26重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
Rho GTP酶激活蛋白26重组兔单抗
货号:bsm-62542R
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概述

产品编号
bsm-62542R
产品类型
重组兔单抗
英文名称
GRAF Recombinant Rabbit mAb
中文名称
Rho GTP酶激活蛋白26重组兔单抗
英文别名
GRAF; GRAF1; OPHN1L; OPHN1L1; 1810044B20Rik; 2610010G17Rik; 4933432P15Rik; mKIAA0621; RHG26_HUMAN; ARHGAP26; GTPase regulator associated with focal adhesion kinase (GRAF1); Oligophrenin-1-like protein; Rho-type GTPase-activating protein 26; KIAA0621; RHG26_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ARHGAP26: 740-814
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8C12
理论分子量
92
检测分子量
100
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria.Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V.
Rho GTP酶激活蛋白26重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
ARHGAP26
蛋白名
Rho GTPase-activating protein 26
亚基
Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.
亚细胞定位
Cell junction; focal adhesion. Cytoplasm; cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.
疾病
Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
相似性
Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain.
功能
GTPase-activating protein for RHOA and CDC42.

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