GRAF Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-62542R

重组兔单抗

GRAF Recombinant Rabbit mAb

Rho GTP酶激活蛋白26重组兔单抗

GRAF; GRAF1; OPHN1L; OPHN1L1; 1810044B20Rik; 2610010G17Rik; 4933432P15Rik; mKIAA0621; RHG26_HUMAN; ARHGAP26; GTPase regulator associated with focal adhesion kinase (GRAF1); Oligophrenin-1-like protein; Rho-type GTPase-activating protein 26; KIAA0621; RHG26_MOUSE; Rho GTPase activating protein 26; GTPase regulator associated with the focal adhesion kinase pp125

Rabbit

A synthesized peptide derived from human ARHGAP26: 740-814

IgG

Liquid

affinity purified by Protein A

Recombinant

8C12

92 kDa

100 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria.Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V.

ARHGAP26

Rho GTPase-activating protein 26

Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.

Cell junction; focal adhesion. Cytoplasm; cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.

Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.

Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain.

GTPase-activating protein for RHOA and CDC42.