Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.
基因名
TXNDC12
蛋白名
Thioredoxin domain-containing protein 12
亚细胞定位
Endoplasmic reticulum.
组织特异性
Widely expressed.
相似性
Contains 1 thioredoxin domain.
功能
ERp19 belongs to the thioredoxin superfamily. Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors. Possesses significant protein thiol-disulfide oxidase activity.