Thiol protease that acts as a mediator of programmed cell death.Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:500-2000
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
CASP5
蛋白名
Caspase-5
亚基
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10kDa (p10) subunits.
组织特异性
Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
相似性
Belongs to the peptidase C14A family. Contains 1 CARD domain.