Aconitase 1 Recombinant Rabbit mAb (一抗) | Bioss
Rrmab?兔单抗
货号：bsm-62433R
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概述
产品编号
bsm-62433R
产品类型
重组兔单抗
英文名称
Aconitase 1 Recombinant Rabbit mAb
中文名称
铁调节蛋白1重组兔单抗
英文别名
ACOHC_HUMAN; ACO1; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1 (IRP1); Iron-responsive element-binding protein 1 (IRE-BP 1); 4.2.1.3; IREB1; ACOHC_MOUSE; Irebp; ACOHC_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Aconitase 1: 15-42/889
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
15B8
理论分子量
98 kDa
检测分子量
90 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing
Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Bifunctional iron sensor that switches between 2 activities depending on iron availability.Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ACO1
蛋白名
Cytoplasmic aconitate hydratase
亚基
Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
亚细胞定位
Cytoplasm.
相似性
Belongs to the aconitase/IPM isomerase family.
功能
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
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