Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity).
基因名
PCBP1
蛋白名
Poly(rC)-binding protein 1
亚细胞定位
Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
组织特异性
Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.
翻译后修饰
Phosphorylated; lowers poly(rC)-binding activity.
相似性
Contains 3 KH domains.
功能
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.