核孔糖蛋白P62重组兔单抗
Rrmab®兔单抗
货号：bsm-62402R
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概述
产品编号
bsm-62402R
产品类型
重组兔单抗
英文名称
NUP62 Recombinant Rabbit mAb
中文名称
核孔糖蛋白P62重组兔单抗
英文别名
IBSN; SNDI; p62; D7Ertd649e; Nupc1; Np62; NUP62_HUMAN; NUP62; 62 kDa nucleoporin; Nucleoporin Nup62; NUP62_MOUSE; NUP62_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human NUP62: 481-522
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9F19
理论分子量
53
检测分子量
70
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Nucleus
Cell Biology > Apoptosis > Nucleus
Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Nuclear Pore Complex
Signal Transduction > Growth Factors/Hormones > EGF
Signal Transduction > Protein Trafficking > Nuclear Import / Export
Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway
Tags & Cell Markers > Subcellular Markers > Nucleus > Nuclear Pore
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The nuclear pore complex is a structure that extends across the nuclear envelope and regulates the flow of macromolecules between the cytoplasm and the nucleus. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 |
交叉反应
交叉反应: Human
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靶标
基因名
NUP62
蛋白名
Nuclear pore glycoprotein p62
亚基
Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1 (By similarity). Interacts with C11orf73/Hikeshi.
亚细胞定位
Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle.
翻译后修饰
O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, amongst which only one in the C-terminal.
疾病
Infantile striatonigral degeneration (SNDI) [MIM:271930]: Neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and mental retardation. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the nucleoporin NSP1/NUP62 family.
功能
Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.
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