三羟基三甲基辅酶A合成酶2重组兔单抗
Rrmab®兔单抗
货号：bsm-62355R
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概述
产品编号
bsm-62355R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
HMGCS2 Recombinant Rabbit mAb
中文名称
三羟基三甲基辅酶A合成酶2重组兔单抗
英文别名
HMCS2_HUMAN; HMGCS2; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 2.3.3.10;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human HMGCS2: 480-508
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
18G13
理论分子量
57
检测分子量
50
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
背景资料
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
HMGCS2
蛋白名
Hydroxymethylglutaryl-CoA synthase, mitochondrial
亚细胞定位
Mitochondrion.
组织特异性
High expression in liver and colon. Low expression in testis, heart, skeletal muscle and kidney.
疾病
Defects in HMGCS2 are the cause of HMG-CoA synthase deficiency (HMGCS deficiency) [MIM:605911]; also known as deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2. Affected individuals present with severe hypoketotic hypoglycemia, mild hepatomegaly, or fatty liver, and a nondiagnostic pattern of urinary organic acids with increase of medium and short chain dicarboxylic acids.
相似性
Belongs to the HMG-CoA synthase family.
功能
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
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