类固醇5α还原酶2重组兔单抗
Rrmab®兔单抗
货号：bsm-62269R
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概述
产品编号
bsm-62269R
产品类型
重组兔单抗
英文名称
SRD5A2 Recombinant Rabbit mAb
中文名称
类固醇5α还原酶2重组兔单抗
英文别名
5ART2; S5AR 2; ST5AR2; S5A2_HUMAN; SRD5A2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2 (S5AR 2); Type II 5-alpha reductase; 1.3.1.22; Q3UTZ9_MOUSE; S5A2_MOUSE; S5A2_PIG; S5A2_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SRD5A2: 1-70/254
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5H4
理论分子量
28
检测分子量
28
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat | 1:500-2000 |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat)
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靶标
基因名
SRD5A2
蛋白名
3-oxo-5-alpha-steroid 4-dehydrogenase 2
亚细胞定位
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).
组织特异性
Expressed in high levels in the prostate and many other androgen-sensitive tissues.
疾病
Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
相似性
Belongs to the steroid 5-alpha reductase family.
功能
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
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