PLCG 2 Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF | Bioss

bsm-62254R

重组兔单抗

PLCG 2 Recombinant Rabbit mAb

磷酯酶Cγ2重组兔单抗

APLAID; FCAS3; PLC-IV; PLC-gamma-2; PLCgamma2; Plcg-2; PLCG2_HUMAN; PLCG2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV (PLC-IV); Phospholipase C-gamma-2 (PLC-gamma-2); 3.1.4.11; PLCG2_MOUSE; PLCG2_RAT; phospholipase C gamma 2; phospholipase C, gamma 2 (phosphatidylinositol-specific)

Rabbit

A synthesized peptide derived from human PLCG2: 711-777/1265

IgG

Liquid

affinity purified by Protein A

Recombinant

5C2

148 kDa

148 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

PLCG2

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2

Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) .

Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.

Defects in PLCG2 are the cause of familial cold autoinflammatory syndrome type 3 (FCAS3) [MIM:614468]. An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B cells, defective B cells, increased susceptibility to infection, and increased risk of autoimmune disorders.

Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 PI-PLC X-box domain.
Contains 1 PI-PLC Y-box domain.
Contains 2 SH2 domains.
Contains 1 SH3 domain.

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.