PHGDH Recombinant Mouse mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号：bsm-60570M
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概述
产品编号
bsm-60570M
产品类型
重组小鼠单抗
英文名称
PHGDH Recombinant Mouse mAb
中文名称
磷酸甘油酸脱氢酶单克隆抗体
英文别名
3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA; 4930479N23; A10; SERA_HUMAN; PHGDH; 2-oxoglutarate reductase; Malate dehydrogenase; 1.1.1.95; PGDH3; SERA_MOUSE; SERA_RAT;
抗体来源
Mouse
亚型
IgG1, Kappa
性状
Liquid
纯化方法
affinity purified by Protein G
克隆类型
Recombinant
克隆号
D12E1
理论分子量
56 kDa
检测分子量
57 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
催化3-磷酸-D-甘油酯可逆氧化为3-磷酸丙酮酸，这是L-丝氨酸磷酸化生物合成途径的第一步。还催化2-羟基戊二酸可逆氧化为2-酮戊二酸和（S）-苹果酸可逆氧化为草酰乙酸。
背景资料
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Rat | Mouse | 1:100-500 |
| IHC-F | Human, Rat | Mouse | 1:100-500 |
| IF | Human, Rat | Mouse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PHGDH
蛋白名
D-3-phosphoglycerate dehydrogenase
亚基
Homotetramer
疾病
Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) . It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
相似性
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
功能
Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.
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